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Most hospitals lack to determine explicit criteria when a patient by a doctor to determine whether the patient the the intensive care unit should be evaluated We need validated standards that prompt urgent bed evaluation of a patient 7 days week 39 percent of a day. Timely physician at the bedside evaluation of hospitalized patients prevent at risk for catastrophic deterioration could, thousands of deaths each year. .. Delay in the transfer to the intensive care increases the risk of deathpatients in a regular hospital ward at the intensive care unit after suffering a deterioration in their vital signs moved like a drop in blood pressure delays or increased breathing rate may be at increased risk of death on to study at the American Thoracic Society International Conference in Orlando 24th In May presented.GalNAz an azide group, which chemically to probes which can be rendered visible, can be marked. The probe responding with the azide of due to phosphine group of, called a the process at Bertozzi laboratory developed which Staudinger, named after a German synthetic-organic chemist and Nobel laureate Herman Staudinger, described first, the reaction between azides and one phosphines virtually 100 few years.
After injection of of mice GalNAz, azide -labeled glycoproteins in a variety of tissues , including liver, kidney and heart were observed, and also in the serum and on isolated splenocytes, is a Unitedby Bertozzi and her co – author state in their PNAS paper. B cells glycoproteins were robustly with GalNAz however T cell glycoproteins of were not labeled, What do fundamental differences in its glycosylation machinery and metabolic. could be In addition GalNAz – labeled B cells accepted selectively , with a phosphine sensor carried Staudinger ligation has selective inside the living veterinary Metabolic labeling to GalNAz by Staudinger provides a means for proteome analysis of posttranslational modifications and for identification O – glycoprotein glycoprotein finger prints associated with with disease .