Publication detailsHolt KE et al. High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi. Nature Genetics, available online in advance of print publication on Sunday, June 2008 click here .
15,000 yearsA differences to track and tackle typhoidThe study is a collaboration between researchers at the Wellcome Trust Sanger Institute, University College Cork, Institut Pasteur in Paris and Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam. The team studied 19 isolates of Typhi from ten countries, with new sequencing methods that meant they could capture the rare signals of genetic variation in this stubborn genome. They produced more than 1.7 billion letters of genetic sequence and found evidence of fewer than 2000 mutation events, which is very little development since the emergence of Typhi at least 15,000 years.