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Chronic idiopathic urticaria: keys to improving quality of life The intense pruritus and evanescent skin lesions of urticaria are tolerated by patients poorly, and long-term disease can result in sleep disturbances, anxiety and reduced standard of living. Nonsedating antihistamines, patient education and mental support form the foundation of management. Urticaria is a comparatively common condition, affecting a quarter of the population at some right time. Although chronic idiopathic urticaria is a nonlife-threatening condition, it can be connected with significant emotional decrease and distress in quality of life.